TRANSMEMBRANE HELICES ARE AN OVER-PRESENTED AND EVOLUTIONARILY CONSERVED SOURCE OF MAJOR HISTOCOMPATIBILITY COMPLEX CLASS I AND II EPITOPES

Transmembrane Helices Are an Over-Presented and Evolutionarily Conserved Source of Major Histocompatibility Complex Class I and II Epitopes

Cytolytic T cell responses are predicted to be biased towards membrane proteins.The peptide-binding grooves of most alleles of histocompatibility complex class I (MHC-I) are relatively hydrophobic, therefore peptide fragments derived from human transmembrane helices (TMHs) are predicted to be presented more often neflintw-r6mpw as would be expected

read more



BUREAUCRATIC CORRUPTION AND LIBERAL SOLUTIONS

There is a common belief that social systems are sensitive to any disruptions due to click here the fit of the individual elements of the social mechanism.That is why bureaucracy was created, as an organizational step towards rationality and efficiency on a large scale.The conditions for getting rich were created by capitalism, but there was a need

read more

A Bicriteria Approach Identifying Nondominated Portfolios

We explore a portfolio constructive model, bostik mvp formulated in terms of satisfaction of a given set of technical requirements, with the minimum number of projects and minimum redundancy.An algorithm issued from robust portfolio modeling is adapted to a vector model, modifying the dominance condition as convenient, in order to find the set of n

read more